KMID : 0605620100170020085
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Journal of Korean Society of Biological Psychiatry 2010 Volume.17 No. 2 p.85 ~ p.92
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The Effect of Depression and Anxiety Symptoms on The Results of Combined Dexamethasone / Corti cotropin-Releasing Hormone Test in Patient s with Schizophrenia
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Lee Sang-Ick Shin Chul-Jin Son Jung-Woo
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Abstract
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Purpose: The aim of this research is to determine the effects of depression and anxiety symptoms of schizophrenic psychopathology on the HPA axis.
Subject and method: Twenty patients with schizophrenia were included and divided into the medication non-exposed group (n=10) and the medication exposed group (n=10). Evaluated scales were the Positive and Negative Syndrome Scale (PANSS), Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS), Hamilton Depression Inventory (HAM-D) and Hamilton Anxiety Inventory (HAM-A), and then the combined Dexamethasone/Corticotropin-Releasing Hormone (DEX/CRH) test was conducted to determine the basal level, the peak level and the area under the curve (AUC) of cortisol and adrenocorticotropic hormone (ACTH).
Results: When the correlations between each psychopathology and cortisol level or ACTH AUC value were analyzed, HAM-D showed a negative correlation, whereas HAM-A showed a positive correlation. Also, the non-depression group (HAM-D¡Â18) showed higher cortisol and ACTH concentrations than the depression group (HAM-D>18), and the anxiety group (HAM-A¡Ã14) showed significantly higher concentrations than the non-anxiety group (HAM-D<14) (P<.05). Also, as for the comparison between the medication non-exposed group and the medication exposed group, the non-exposed group showed significantly higher cortisol and ACTH concentration than exposed group (P<.05).
Conclusion: This study suggest that anxiety symptoms rather than depression symptoms are related to the increased activity of the HPA axis of schizophrenics.
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KEYWORD
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schizophrenia, HPA axis, anxiety, depression
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